The U.S. Department of Agriculture’s Animal and Plant Health Inspection Service (APHIS) announced its determination that the modified Venezuelan equine encephalitis virus (VEEV) strain TC-83(A3G) has demonstrated increased pathogenicity and lethality and that the strain has the potential to pose a severe threat to animal health or animal products. APHIS is advising the public that the strain is subject to APHIS' select agent and toxin regulations effective September 1, 2022.