The Food and Drug Administration (FDA) is proposing an information collection relating to regulations providing that “animal protein derived from mammalian tissue (with some exclusions) is not generally recognized as safe for use in ruminant feed.” These regulations require renderers, feed manufacturers, and others involved in feed and feed ingredient manufacturing and distribution to maintain written procedures specifying the cleanout procedures or other means and specifying the procedures for separating products that contain or may contain protein derived from mammalian tissue from all other protein products from the time of receipt until the time of shipment. The FDA’s information collection aims to better prevent the spread of bovine spongiform encephalopathy and other diseases by determining the degree of compliance with the regulation by such entities. The FDA is accepting public comments on the proposed information collection through September 12, 2022.